Come Dance With Me (202?) stars as Herself/Host
The Rookie(2021) guest stars as Bailey Nune
Robot Chicken(2020) guest stars as Unknown (voice)
Flirty Dancing(2019–2020) stars as Herself/Host
Soundtrack(2019) stars as Joanna
The Resident(2018–2019) guest stars as Julian Booth
Blaze and the Monster Machines(2018) guest stars as Little Bunny (voice)
World of Dance (2017) stars as Host / Mentor
Man With A Plan (2017) guest stars as Jen
No Tomorrow (2016) guest stars as Tuesday
Supergirl (2015) guest stars as Lucy Lane
The Mindy Project (2014) guest stars as Brooke
Witches of East End (2013) stars as Freya Beauchamp
American Horror Story (2012) guest stars as Teresa Morrison
The Playboy Club (2011) stars as Janie / Bunny Janie
Melrose Place (2009) guest stars as Kendra Wilson
Joey (2005) guest stars as Tanya
The Young and the Restless (2004) guest stars as Donna
Quintuplets (2004) guest stars as Haley
Berlin, I Love You (2019) stars as Mandy
The Wedding Year (2019) stars as Jessica
She Made Them Do It (2013) stars as Sarah
Slightly Single in L.A. (2013) stars as Hallie
10 Years (2012) stars as Jess
Balls to the Wall (2011) stars as Rachel Matthews
Set Up (2011) stars as Mia
The Legend of Hell’s Gate: An American Conspiracy (2011) stars as Katherine Prescott
The Jerk Theory (2010) stars as Molly Taylor
American Virgin (2009) stars as Priscilla
The Six Wives of Henry Lefay (2009) stars as Sarah Jane
Falling Awake (2009) stars as Alessandra
Assorted Nightmares: Janitor (2008) stars as Jennifer
Fab Five: The Texas Cheerleader Scandal (2008) stars as Emma Carr
Love Lies Bleeding (2008) stars as Amber
Take the Lead (2006) stars as Sasha
Step Up (2006) stars as Nora Clark
The Grudge 2 (2006) stars as Sally
Waterborne (2005) stars as Devi
Tamara (2005) stars as Tamara Riley
Dark Shadows (2004) stars as Sophia
The Hot Chick (2002) stars as Bianca Salsa Girl
Dewan first appeared in Janet Jackson’s “Doesn’t Really Matter” video, and later in “All for You” and the All for You Tour. Dewan credits working with Jackson for aiding her career, allowing her to later work with many other artists and giving her the experience necessary to co-star in the dance film Step Up. In 2016, Dewan-Tatum modeled as the face of Danskin in a campaign and photo shoot that captured and featured her athleticism as a dancer.
In 2006, Dewan co-starred with Channing Tatum in Step Up, as well as starring in Take the Lead that same year.
In August 2008, Dewan starred in the Lifetime made-for-television film Fab Five: The Texas Cheerleader Scandal which follows five rule-breaking teens. She portrayed the role of disciplinarian Coach Emma Carr. In November 2009, she appeared in the straight-to-DVD comedy American Virgin alongside Rob Schneider.
In March 2011, Dewan was cast in the NBC pilot of The Playboy Club. In May 2011, NBC picked up the series for a full season. She portrayed the role of Bunny Janie, a provocative Playboy bunny who works at a Playboy Club in Chicago in 1961. The series premiered on September 19 to 5.2 million viewers with mixed reviews from critics. Due to low ratings, NBC cancelled the series after just three episodes in October 2011.
In November 2011, Dewan starred in the film The Jerk Theory. This was first released in Germany in 2009. It was later released in the US in November 2011.
Dewan appeared in the romantic-comedy film 10 Years, produced by her husband Channing Tatum. The film was released on September 14, 2012. That same year, she appeared in American Horror Story: Asylum, the second season of the horror television series, as Teresa Morrison.
In 2013, Dewan began starring in the Lifetime series Witches of East End as Freya Beauchamp, one of the lead characters. In late 2015, she began a recurring role in the CBS series Supergirl playing Lucy Lane, the sister of Lois Lane and girlfriend of James Olsen.